In a paper, discuss an important clinical question or re-searchable problem. Frame the question in PICO format: P – Patient / problem – Identify the problem of the patient I – Intervention – Ask what is the intervention you are considering and using C Comparison – Compare the interventions with alternative ones O Outcome – what do you hope to accomplish Identify the economic, legal, and political factors that may affect the implementation of a practice change. References must be from peer-reviewed NURSING journals less than 5 y/o. National, professional, governmental, or educational organizations may be used as supplemental references (.org, .gov, and .edu).